Canine KIM1/TIM1 Antibody

$322.00$847.00

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Catalog #: ABCESPA1381
Product Features
Immunogen: Recombinant Canine HAVCR1 protein 
Clonality:  Rabbit MAb
Cloneno: 202
Isotype: Rabbit IgG
Buffer: 0.2 μm filtered solution in PBS with 5% trehalose
Reactivity: Canine
Specificity: Canine KIM-1 / TIMD-1 / HAVCR1
Application: ELISA, IHC-P
Recommend dilution:  ELISA: 0.1-0.2 μg/mL. This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Canine TIMD1. The detection limit for Canine TIMD1 is approximately 0.00975 ng/well.      IHC-P: 0.5-2 μg/mL
Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Background: Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
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