Cynomolgus CD40 Antibody

$322.00$847.00

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Catalog #: ABCESPA1453
Product Features
Immunogen: Recombinant Cynomolgus CD40 / TNFRSF5 protein 
Clonality:  Rabbit PAb 
Cloneno:
Isotype: Rabbit IgG
Buffer: 0.2 μm filtered solution in PBS
Reactivity: Cynomolgus
Specificity: Cynomolgus CD40 / TNFRSF5
Application: ELISA
Recommend dilution:  ELISA: 0.1-0.2 μg/mL. This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Cynomolgus CD40 / TNFRSF5. The detection limit for Cynomolgus CD40 / TNFRSF5 is 0.00975 ng/well.
Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Background: CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
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