| Product Features | |
|---|---|
| Immunogen: | Recombinant Cynomolgus OLR1 / LOX1 protein |
| Clonality: | Rabbit PAb |
| Cloneno: | |
| Isotype: | Rabbit IgG |
| Buffer: | 0.2 μm filtered solution in PBS with 5% trehalose |
| Reactivity: | Cynomolgus |
| Specificity: | Cynomolgus OLR1 / LOX1 |
| Application: | ELISA |
| Recommend dilution: | ELISA: 0.5-1 μg/mL. This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Cynomolgus OLR1 / LOX1. The detection limit for Cynomolgus OLR1 / LOX1 is approximately ≤ 0.039 ng/well. |
| Storage: | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
| Background: | Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is inducted by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions. |
Cynomolgus OLR1 Antibody
$322.00 – $847.00