| Product Features | |
|---|---|
| Immunogen: | Recombinant Rhesus IGFBP-2 / IGFBP2 protein |
| Clonality: | Mouse MAb |
| Cloneno: | 4 |
| Isotype: | Mouse IgG2a |
| Buffer: | 0.2 μm filtered solution in PBS |
| Reactivity: | Cynomolgus |
| Specificity: | Rhesus IGFBP-2 / IGFBP2No cross-reactivity in ELISA withCynomolgus IGFBP1Human cell lysate (293 cell line) |
| Application: | ELISA |
| Recommend dilution: | ELISA: 0.5-1 μg/mL. This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rhesus IGFBP-2 / IGFBP2. The detection limit for Rhesus IGFBP-2 / IGFBP2 is approximately 0.078 ng/well. |
| Storage: | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
| Background: | IGFBP-2, also known as IGFBP2, is a insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs , control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified. The six IGFBPs are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to a potential involvement of IGFBP-2 in tumorigenesis. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates. |
Rhesus IGFBP2 Antibody
$322.00 – $847.00