The term PEGylation describes the process of both covalent and non-convalent modification of biological molecules, such as Peptides, Proteins, Nucleic acids, Antibodies, Nanoparticles and Surfaces, with polyethylene glycol (PEG). In general, PEGylation improves the aqueous solubility and biostability of organic molecules through changing their physical and chemical properties. The most important thing for a successful PEGylation is to choice a suitable functionalized PEGylation reagent, which is based on the type of available reactive group on the molecules that will be coupled to the PEG. Listed below are selected literatures of successful PEGylation processes.
PEGylation books and reviews
Regents for the Covalent Attachment of mPEG to Peptides and Proteins, Handbook of Polymers for Pharmaceutical Technologies, Structure and Chemistry, Chapter 3, Gonzalez, M., Vaillard, V.A., Vaillard, S.E., 2015, 51-83.
Recent Applications of Polyethylene Glycols (PEGs) and PEG Derivatives, Modern Chemistry & Applications, Hutanu, D., Frishberg, M. D., Guo, L., Darie, C.C., 2014. DOI:10.4172/2329-6798.1000132
Carbohydrate PEGylation, an approach to improve pharmacological potency, Beilstein Journal of Organic Chemistry, Giorgi, M. Eugenia Agusti, Rosalía de Lederkremer, Rosa M., 2014, 10, 1433-1444, DOI: 10.3762/bjoc.10.147
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives, Angewandte Chemie International Edition, Knop, K., Hoogenboom, R., Fischer, D., Schubert, U. S., 2010, 49, 6288-6308, DOI: 10.1002/anie.200902672.
PEGylation, successful approach to drug delivery, Drug Discovery Today, Veronese, F. M. Pasut, G., 2005, 10, 1451-1458, DOI: http://dx.doi.org/10.1016/S1359-6446(05)03575-0.
mPEG-Maleimide: Cys34-PEGylated Human Serum Albumin for Drug Binding and Delivery, Bioconjugate Chem., 2015, 26 (5), pp 941–949. Link: http://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.5b00143.
mPEG-Maleimide: Peptide GE11–Polyethylene Glycol–Polyethylenimine for targeted gene delivery in laryngeal cancer, Medical Oncology, 2015, DOI: 10.1007/s12032-015-0624-9.
mPEG-Maleimide: PEGylated recombinant human interferon-ω as a long-acting antiviral agent: Structure, antiviral activity and pharmacokinetics, Antiviral Research, 2014, 108, 142-147, Link: http://www.sciencedirect.com/science/article/pii/S016635421400165X.
mPEG-Amine: 1,1-Disubstituted-2-vinylcyclopropanes for the synthesis of amphiphilic polymers, European Polymer Journal, 2015, 66, 319-327. Link: http://www.sciencedirect.com/science/article/pii/S0014305715000981.
mPEG-Amine: Tumor Intracellular-Environment Responsive Materials Shielded Nano-Complexes for Highly Efficient Light-Triggered Gene Delivery without Cargo Gene Damage, Advanced Functional Materials, 2015, 25, 3472-3482. Link: http://onlinelibrary.wiley.com/doi/10.1002/adfm.201500737/abstract.
mPEG-Alkyne: N-PEG’ylation of chitosan via “click chemistry” reactions, React. Funct. Polym. 2009, 69, 771–778. Link: http://www.sciencedirect.com/science/article/pii/S1381514809001357.
mPEG-Acid: Multifunctional dendrimer-entrapped gold nanoparticles for dual mode CT/MR imaging applications, Biomaterials, 2013, 34, 5200-5209. Link: http://www.sciencedirect.com/science/article/pii/S0142961213002913.
mPEG-Thiol: NPC Mimics: Probing the Mechanism of Nucleocytoplasmic Transport, Methods Cell Biol. 2014, 122, 379–393. Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272007/.
mPEG-Thiol: Photoacoustic and ultrasound imaging using dual contrast perfluorocarbon nanodroplets triggered by laser pulses at 1064 nm, Biomedical Optics Express, 2014, 5, 3042-3052. Link: https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-5-9 3042&id=298802.