Dear Customer,
On behalf of our entire team, we want to wish you a joyous Holiday Season filled with health, love and laughter.
This year, we’re thankful for you – our loyal customers who continue to trust us as a partner in your work. And we hope to have the pleasure of doing business with you for many years to come.
Merry Christmas and Happy New Year!
Advanced BioChemicals Team
Save more money and time for your research projects with hundreds of available Advanced BioChemicals’ products. Please enjoy our special EASTER SALES PROMOTION with UP TO 20% OFF discount.
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Welcome to download our NEW 2017 Catalog (PEG, Magnetic Beads, ELISA Kits)!
Advanced BioChemicals (ABC) make your research easy and affordable. We are glad to offer NEW Discrete (Monodisperse) Polyethylene Glycols and FREE Antibodies. Please contact us for detail and more information.
Welcome to download our NEW 2017 Catalog (PEG, Magnetic Beads, ELISA Kits)!
Advanced BioChemicals (ABC) makes your research easy and affordable. Check the availability of your FREE Antibodies and Magnetic Beads sample now. Please contact us for detail and more promotions.
Dear Customer,
On behalf of our entire team, we want to wish you a joyous Holiday Season filled with health, love and laughter.
This year, we’re thankful for you – our loyal customers who continue to trust us as a partner in your work. And we hope to have the pleasure of doing business with you for many years to come.
Three Offers to be thankful for your supports:
Please contact us for detail.
Merry Christmas and Happy New Year!
Sincerely!
Advanced BioChemicals Team
Save on some of our most popular products through Black Friday
You don’t need to wait until Thanksgiving to save big at Advanced BioChemicals. Starting today, we are offering up to 20% OFF select our popular products through November 25.
The sale includes some of our most popular PEG products, Magnetic Beads, ELISA Kits and Antibodies. Take advantage of our special promotion and save!
Products on sale are listed below:
Please contact us for more details and discounts!
First patient in the Lambda Interferon MonoTherapy in HDV clinical study has been dosed with pegylated interferon lambda-1a, a potential therapeutic for chronic hepatitis D virus infection announced by Eiger BioPharmaceuticals Inc. And now multiple active anti-HDV agents have been in development, including an oral therapy and a subcutaneous injectable therapy to study alone and in combination toward the suppression or cure of HDV, per the release.
Pegylated interferon lambda-1a, known as lambda, is a well-characterized, late-stage, first in class, type III interferon (IFN) that stimulates immune responses that are critical for the development of host protection during viral infections.
“Over recent years, patients with chronic hepatitis B and hepatitis C have benefited from huge advances in antiviral therapy for both diseases,” Edward Gane, MD, chief hepatologist, transplant physician and deputy director of the New Zealand Liver Transplant Unit, Auckland City Hospital, and investigator in the LIMT HDV study, said in the release. “Unfortunately, HDV remains a huge unmet medical need because of the lack of any effective therapy for this most aggressive form of viral hepatitis. … We are delighted to have enrolled the first patient in LIMT HDV, a study that may lay the groundwork for development of Lambda in HDV infection.”
Fall Savings Promotion!
Save even more money and time for your research projects with a range of over 400 PEG products that have been developed for use in a wide variety of application, such as PEGylated protein drug, PEGylated nano-particles like liposome and polymer micelles, PEG Hydrogels, and PEG linker for antibody conjugated nano-particles.
Please enjoy our time-limited Fall Savings Promotion!
Please contact us for more details and discounts!
Advanced BioChemicals offers a broad range of PEG products to help you meet your research needs every day. Don’t just take our word, try our free samples and enjoy high quality results. It’s risk-free! But hurry, there are a limited number of free samples available!
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Summer may bring the heat, but it also brings the Hot Deals!
Save even more money and time for your research projects with hundreds of available PEG products.
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Selected PEG products price after up to 20% off:
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Advanced BioChemicals (ABC) greatly appreciate your business and support. In order to feedback your supports, $5, $10, $15, $20 and $40 Amazon gift card will be shipped with your order when the amount reaches $0-$200, $200-$500, $500-$750, $750-$1000 and over $1000, respectively.
Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications
How to choose the right PEG product to meet the requirements for specific applications? A new review provides guidance to formulators on the appropriate PEG grade selection for particular application of PEG based on the available in vitro and in vivo data. (Read full publication…)
Advanced BioChemicals (ABC) offer various high quality linear and multi-arm PEG products with a broad range of molecular weight. Please contact us for free quotation and more discount.
May Promotions:
5% Off discount on all mPEG products until May 31, 2016.
Advanced BioChemicals (ABC) greatly appreciate your business and support. In order to feedback your supports, $5, $10, $15, $20 and $40 Amazon gift card will be shipped with your order when the amount reaches $0-$200, $200-$500, $500-$750, $750-$1000 and over $1000, respectively.
The effect of PEGylation on the stimulation of IL-1β by gold (Au) nanoshell/silica core nanoparticles
How would PEGylation affect the generation and scavenging reactive oxygen species (ROS) by Au nanoshell/silica core (GNS) nanoparticles? Would PEG attenuate or enhance the ability of GNS nanoparticles in inducing the secretions of IL-1β? The new results show that surface modification of GNS nanoparticles or other nanoparticles by PEGylation can potentially reduce the probability of stimulating the production of ROS and IL-1β. (Read full publication…)
Advanced BioChemicals (ABC) offer various high quality linear and multi-arm PEG products with a broad range of molecular weight. Please contact us for free quotation and more discount.
May Promotions:
5% Off discount on all mPEG products until May 31, 2016.
Advanced BioChemicals (ABC) greatly appreciate your business and support. In order to feedback your supports, $5, $10, $15, $20 and $40 Amazon gift card will be shipped with your order when the amount reaches $0-$200, $200-$500, $500-$750, $750-$1000 and over $1000, respectively.
“Sheddable” PEG-lipid to balance the contradiction of PEGylation between long circulation and poor uptake
How to balance the contradiction between the advantages of long circulation and the disadvantages of poor uptake of PEGylated lipids? A new “sheddable” PEG-lipid micelle system has been developed based on the conjugation of PEG and phosphatidyl ethanolamine (DSPE) with a pH sensitive benzoic imine bond, which successfully solves this problem and has been proved to be a good candidate for effective intracellular drug delivery in cancer chemotherapy. How does it work? (Read full publication…)
Advanced BioChemicals (ABC) offer various high quality linear and multi-arm PEG products with a broad range of molecular weight. Please contact us for free quotation and more discount.
May Promotions:
5% Off discount on all mPEG products until May 31, 2016.
Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic phase chronic myeloid leukemia patients
The addition of pegylated interferon-ɑ2b (PegIFN) to the tyrosine kinase inhibitor (TKI) dasatinib yielded promising results in 40 newly diagnosed chronic myeloid leukemia (CML) patients. At the 3-month mark prior to initiation of PegIFN, 10% of patients achieved a major molecular response (MMR) and 66% achieved a complete cytogenetic remission (CCgR). The results published in Leukemia suggest that combining dasatinib with PegIFN may increase the chance of achieving long-standing treatment-free remission. (Read full publication…)
Advanced BioChemicals (ABC) offer various high quality linear and multi-arm PEG products with a broad range of molecular weight. We also offer custom synthesis service to support your research. We have increased in stock of inventories, please contact us for free quotation and detail.
May Promotions:
5% Off discount on all mPEG products until May 31, 2016.
Advanced BioChemicals (ABC) greatly appreciate your business and support. In order to feedback your supports, $5, $10, $15, $20 and $40 Amazon gift card will be shipped with your order when the amount reaches $0-$200, $200-$500, $500-$750, $750-$1000 and over $1000, respectively.
Large-Scale Biophysical Evaluation of Protein PEGylation Effects: In Vitro Properties of 61 Protein Entities
Only limited public data is available on the biophysical effects of protein PEGylation, even though PEGylation is the most widely used method to chemically modify protein biopharmaceuticals. The first large-scale study, with site-specific mono-PEGylation of 15 different proteins and characterization of 61 entities using a common set of analytical methods was reported in a recent publication. (Read full publication…)
Advanced BioChemicals (ABC) offer various high quality linear and multi-arm PEG products with a broad range of molecular weight. We also offer custom synthesis service to support your research. We have built up our stocks, please contact us for free quotation and detail.
April Promotions:
10% Off discount on all Thiol PEG products until April 30, 2016.
Advanced BioChemicals (ABC) greatly appreciate your business and support. In order to feedback your supports, $5, $10, $15, $20 and $40 Amazon gift card will be shipped with your order when the amount reaches $0-$200, $200-$500, $500-$750, $750-$1000 and over $1000, respectively.
Review: Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional PEG linker
Gold nanoparticles (AuNPs) have the potential for early detection, accurate diagnosis and personalized treatment of cancer, which have been exploited for various treatment modalities including photothermal ablation therapy, radio sensitization, imaging and drug delivery. To create a clinically relevant AuNP treatment, the surface must be functionalized with multiple ligands such as drugs, antifouling agents and targeting moieties. PEG or the lower molecular weight oligo ethylene glycol (OEG) are the most widely adopted antifouling agents. This review compares the two most widely employed methods of surface co-functionalization, namely mixed monolayers and hetero-bifunctional linkers. (Read full review …)
Advanced BioChemicals (ABC) offer various high quality linear and multi-arm thiol PEG products with a broad range of molecular weight. We also offer custom synthesis service to support your research. We have adjusted the price of most PEG products, please view and download our latest 2016 ABC-PEG Products Catalog for detail.
April Promotions:
10% Off discount on all Thiol PEG products until April 30, 2016.
Advanced BioChemicals (ABC) greatly appreciate your business and support. In order to feedback your supports, $5, $10, $15, $20 and $40 Amazon gift card will be shipped with your order when the amount reaches $0-$200, $200-$500, $500-$750, $750-$1000 and over $1000, respectively.
Please contact us for free quotation and detail.
Review: Onto better TRAILs for cancer treatment
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF cytokine superfamily, has been described to be capable of inducing apoptosis selectively in cancer cells. This review summarizes second-generation novel formulations of TRAIL and other TRAIL-R agonists, which exhibit enhanced cytotoxic capacity toward cancer cells. PEGylated versions using site-specific N-terminal PEGylation of izTRAIL showed widely improved pharmacokinetic profiles in vivo and, furthermore, greatly augmented stability and solubility under physiological conditions. (Read full review…)
Advanced BioChemicals (ABC) offer various high quality linear and multi-arm Amino PEG products with a broad range of molecular weight. Please view and Download our 2016 ABC-PEG Products Catalog for more PEG products.
ABC Linear and Multi-arm Amino PEG:
March Promotions:
10% Off discount on all Amino PEG products until March 31, 2016.
Advanced BioChemicals (ABC) greatly appreciate your business and support. In order to feedback your supports, $5, $10, $15, $20 and $40 Amazon gift card will be shipped with your order when the amount reaches $0-$200, $200-$500, $500-$750, $750-$1000 and over $1000, respectively.
Please contact us for free quotation and detail.
Medical was the largest application for PEG, accounting for more than 40% of market share in 2013. Superior blending, hygroscopicity and non-toxic properties of PEG have resulted in high demand for the chemical in numerous pharmaceutical products such as tablets and ointments. Increasing use of PEG as a solvent in the manufacturing of laxatives and eye drops coupled with the growth of pharmaceutical industry is anticipated to drive market. Evolution of waterborne coating and paint in automotive and construction industries owing to growing demand for eco-friendly products is expected to augment PEG market growth.
Read the full research report at: http://www.radiantinsights.com/research/polyethylene-glycol-peg-market-analysis-by-application-medical-personal-care-industrial-and-segment-forecasts-to-2020.
Advanced BioChemicals (ABC) offer various high quality linear and multi-arm PEG products with a broad range of molecular weight. Please view and Download our 2016 ABC-PEG Products Catalog.
To support your research needs, Advanced BioChemicals offers various PEG derivatives to meet your project requirements. View and Download our 2016 ABC-PEG Products Catalog.
Promotions
10% Off discount on all PEG products until February 29th, 2016. Please contact us for detail.
Do you spend a lot of time, money and resources in producing PEGylated materials? If that’s the case, our newly launched various novel PEG derivatives are for you. Get flexible scale, high quality at desired purity without the hassle. Check the price and availability of ABC PEG products now.
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Results of purity analysis by NMR and HPLC of ABC PEG products and other market PEG products:
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10% OFF on all PEG products until February 29th, 2016. Please contact us for detail.
Looking for better magnetic beads to get more purified proteins in order to save more money and time? The new nanoscale superparamagnetic beads can help you!
Advantages of Nanoscale superparamagnetic beads from Advanced BioChemicals (ABC):
pH Stability and binding capacity of nanoscale super-paramagnetic beads from Advanced BioChemicals (ABC):
Need small amount of PEG or Magnetic Beads but don’t want to pay more? Free PEG and Free Magnetic Beads promotion are back! Advanced BioChemicals (ABC) make research easy and affordable. Check the availability of your free PEG and Magnetic Beads sample now.
Advanced BioChemicals (ABC) greatly appreciate your business and support. In order to feedback your supports, $5, $10, $15, $20 and $40 Amazon gift card will be shipped with your order when the amount reaches $0-$200, $200-$500, $500-$750, $750-$1000 and over $1000, respectively.
Various new PEG and magnetic beads products are available now, including:
Please contact us for price and availability.
Dear Customer,
On behalf of our entire team, we want to wish you a joyous Holiday Season filled with health, love and laughter.
This year, we’re thankful for you – our loyal customers who continue to trust us as a partner in their work. And we hope to have the pleasure of doing business with you for many years to come.
Three Offers to be thankful for every day:
Merry Christmas and Happy New Year!
Advanced BioChemicals Team
(Offers are available from Dec 1, 2015 to Jan 31, 2016)
A new method to produce site specifically PEGylated or bivalent single-domain antibodies has been developed by Prof. Steven Liang group at Harvard University (Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics, Angew. Chem. Int. Ed., DOI: 10.1002/anie.201507596).
They used camelid single-domain antibody fragments (VHHs) as the smallest antigen-binding derivatives, which lend themselves to enzymatic modification and have been used in a variety of applications, including imaging. They found that the antibody-PEG conjugation reaction conditions enable full retention of the biological activity of the fusion partners. And the attachment of small PEG groups could be used as a tool to “tune” the persistence of a VHH in the circulation. Moreover, PEGylation can decrease the immunogenicity of VHHs, which is important in cases in which repeated administration is required. The PEGylated fluorescent VHHs showed improved staining in vivo, with larger PEG substituents giving stronger signals in FACS, whereby PEG substituents with a higher molecular weight gave stronger signals. Finally, immune-PET of two different models of tumor-bearing mice showed that the DC8 dimer and DC13 dimer detected not only lymphoid organs, as expected, but also showed the location of ectopic melanoma and pancreatic tumor grafts.
Advanced BioChemicals (ABC) offer various high quality PEG products with a broad range of molecular weight. Visit Advanced BioChemicals (ABC) PEG products website to find more details.
Original manuscript: onlinelibrary.wiley.com/doi/10.1002/anie.201507596/abstract
As the first successful technology to improve pharmacokinetic (PK) profiles of therapeutic agents, PEGylation has been widely used to stabilize bioactive molecules (proteins, peptides, enzymes, antibody fragments, oligonucleotides, small synthetic drugs, ets.). As indicated by Prof. Lee in his new manuscript, over 10 PEGylated drugs have been approved by the FDA to date with over 20 drugs in clinical trials and it was estimated that PEGylated drugs would be a multi-billion dollar market.
Since its discovery, PEG chemistry experienced enormous enhancement. First-generation PEGylation involved random PEG conjugation along the biomolecule that showed varying physicochemical and pharmaceutical properties. Second-generation PEGylation took the benefits from an array of PEG derivatives – activated PEG molecules, higher molecular weight PEG polymers and branched PEG structures, which enable to make site-specific PEGylation and further improve the PK profiles. Now third-generation technologies aim to preserve the drug’s bioactivity.
Third-generation PEGylation looks to minimize the current trade-off between potency and circulation half-life for longer-lived drugs. One technique is to utilize customized linker to make releasable PEG conjugates as a predrug approach or create customizable PEGylation sited on proteins. Another approach is to use unique PEG with customized sizes and shapes to affect therapeutic potency of the parent molecule.
Advanced Biochemicals (ABC) offer various linear and branched PEG products. We also provide customer PEG synthesis and customer PEGylation service with different molecular weight and structure .
Original Paper: http://www.tandfonline.com/doi/full/10.1517/14728214.2015.1113254
A series of PEG covered bimetallic (Au-Pd) nanostructures have been developed by Prof. R. D. Tilley group (University of New South Wales, Australia), which have shown high efficiency of photothermal hyperthermia therapy. In order to stabilize the bimetallic nanostructure for in vitro and in vivo hyperthermia studies, poly(ethylene glycol) diamine (H2N-PEG-NH2) was chosen as the surfactant to conjugated with the bimetallic nanastructes through a simple ligand exchange process. Furthermore, the long PEG backbone is effective for imparting steric stability, preventing aggregation of the nanostructures. Surface modification with PEG products also ensures good tumor uptake of nanomaterials and minimizes immunological response. These PEG products modified Au-Pd bimetallic nanostructures irradiated with 808 nm laser light caused destruction of HeLa cells in vitro, as well as complete destruction of tumor xenographs in mouse model in vivo for effective photothermal hyperthermia. [Reference: http://pubs.acs.org/doi/abs/10.1021/acsnano.5b05563]
Advanced BioChemicals (ABC) offer various high quality PEG products with a broad range of molecular weight. Visit Advanced BioChemicals (ABC) PEG products website to find more details.
According to a new market research report “ Nucleic Acid Isolation and Purification Market by Product (Reagents, Kits, Instruments), Technology (Column-, Reagent-, Magnetic Bead-based), Application (Plasmid, Genomic DNA, miRNA, Total RNA, PCR Clean-up), & End Users – Global Forecast to 2020 “, published by MarketsandMarkets.com (November 2015), The global Nucleic Acid Isolation and Purification Market is expected to reach USD 3,837.42 Million by 2020 from USD 2,560.31 Million in 2015, growing at a CAGR of 8.43% between 2015 and 2020.
Nucleic acid isolation and purification is a set of molecular biology techniques used for the extraction of DNA and RNA for use in downstream applications. Among all these techniques, magnetic bead-based isolation and purification have attracted considerable attentions due to their unique characters.
Advanced BioChemicals (ABC) magnetic beads have several advantages over similar products:
Visit Advanced BioChemicals (ABC) magnetic beads website to find more details.
10% off All Heterobifunctional PEG Products and Amazon Gift Card Promotion
Advanced BioChemicals (ABC) Make Research Easy and Affordable. Now you can enjoy 10% off on all Heterobifunctional PEG products when you place an order by November 30. Welcome to submit a request for a free quote.
Various new 4-Arm PEG products are available now, including 4-Arm Azide, 4-Arm Acrylate, 4-Arm Isocyanate, 4-Arm Thiol, 4-Arm Acid, 4-Arm Alkyne, with a broad range of molecular weight. Please contact us for price and availability.
Advanced BioChemicals (ABC) greatly appreciate your business and support. In order to feedback your supports, $5, $10, $15, $20 and $40 Amazon gift card will be shipped with your order when the amount reaches $0-$200, $200-$500, $500-$750, $750-$1000 and over $1000, respectively.
4-Arm PEG products are good cross-linkers and have been widely studied in medical field and bioorganic material fields, such as the preparation of hydrogel, drug development, 3D cell culture.
From November 2015, several new high quality of 4-Arm PEG products start to be offered by Advanced BioChemicals (ABC) with different molecular weight (2kDa, 5kDa, 10kDa and 20kDa) and pack size (500mg, 1g, 5g and 10g) .
4-Arm Poly(ethylene glycol) succinimidyl carboxymethyl ester (4-Arm PEG-SCM)
4-Arm Poly(ethylene glycol) succinimidyl ester (4-Arm PEG-SC)
4-Arm Poly(ethylene glycol) alkyne (4-Arm PEG-ALK)
4-Arm Poly(ethylene glycol) azide (4-Arm PEG-N3)
4-Arm Poly(ethylene glycol) isocyanate (4-Arm PEG-NCO)
4-Arm Poly(ethylene glycol) aldehyde (4-Arm PEG-CHO)
4-Arm Poly(ethylene glycol) thiol (4-Arm PEG-SH)
4-arm Poly(ethylene glycol) glutamidyl acid (4-Arm PEG-GAA)
4-Arm Poly(ethylene glycol) glutarate acid (4-Arm PEG-GA)
4-Arm Poly(ethylene glycol) succinimidyl acid (4-Arm PEG-SAA)
4-Arm Poly(ethylene glycol) succinate acid (4-Arm PEG-SA)
4-Arm Poly(ethylene glycol) carboxylic acid (4-Arm PEG-CM)
4-Arm methoxypoly(ethylene glycol) maleimide (4-Arm PEG-MAL)
4-Arm Poly(ethylene glycol) methacrylate (4-Arm PEG-MA)
4-Arm methoxypoly(ethylene glycol) (4-Arm PEG-OH)
Different MW of 4-Arm PEG products may be available by custom synthesis, please email us at tech@advancedbiochemicals.com for details. Advanced BioChemicals (ABC) also provides repackaging services, please contact us at for a free quote, and if you have any questions about our products, please contact us by info@advancedbiochemicals.com or +1-678-827-9993.
Need a small amount PEGs sample for your research and project? Search our PEG product database and enjoy a free PEG sample for a limited time. Please contact us to submit your request. We will deliver your interested sample quickly.
Advanced BioChemicals (ABC) provide high quality PEGs products, include structurally and functionally diversified derivatives of linear (Mono, Homo and Hetero-functional) or multi-arms (2, 4, and 8-arms) polyethylene glycol reagents with a broad range of molecular weight options from -50 (oligomers) to 40 kDa.
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News: 09/24/2015, PEG products are online now!