Writing in Nature Nanotechnology
(online: 2/15/2016, read the full text publication: http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2015.330.html
), Frederik Wurm and colleagues now challenge our understanding of how neutral hydrophilic polymers alter the biological fate of nanoparticles. A polystyrene nanocarriers that have been modified with PEG
have been exposed to plasma proteins exhibit a low cellular uptake, which show that in addition to reducing protein adsorption, PEG
can affect the composition of the protein corona that forms around nanocarriers, and the presence of distinct proteins is necessary to prevent non-specific cellular uptake.
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