Cynomolgus CD200RLa Antibody


Catalog #: ABCESPA1263
Product Features
Immunogen: Recombinant Cynomolgus CD200RLa protein 
Clonality:  Rabbit PAb 
Isotype: Rabbit IgG
Buffer: Produced in rabbits immunized with purified, recombinant Cynomolgus CD200RLa (rC CD200RLa; Catalog#11576-C08H; Met 1-Leu 240). CD200RLa specific IgG was purified by cynomolgus CD200RLa affinity chromatography .
Reactivity: Cynomolgus
Specificity: Cynomolgus CD200RLa
Application: ELISA
Recommend dilution:  ELISA: 0.1-0.2 μg/mL. This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Cynomolgus CD200rla. The detection limit for Cynomolgus CD200rla is approximately 0.00975 ng/well.
Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Background: Cell surface glycoprotein CD200  receptor 2, also known as Cell surface glycoprotein CD200 receptor 1-like, Cell  surface glycoprotein OX2 receptor 2, CD200 receptor-like 2, CD200Rla, CD200R1L  and CD200R2, is a single-pass type I membrane protein which belongs to  the CD200R family. CD200R1L / CD200R2. It contains one Ig-like  C2-type (immunoglobulin-like) domain and one Ig-like V-type  (immunoglobulin-like) domain. CD200 is a transmembrane protein delivering  immunoregulatory signals after engagement of CD200R. A family of CD200Rs exist  ( CD200R1, CD200R2, CD200R3, CD200R4 ) with different tissue expression and  functional activity. In the presence of anti-CD200R2 / CD200R3 monoclonal  antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin  [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into  dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the  relatively ubiquitously expressed molecule CD200 and one of its receptors,  CD200R1, resulted in direct suppression of alloreactivity, engagement of  alternate receptors led instead to altered differentiation of dendritic cells  (DCs) from marrow precursors, which could in turn foster development of  Foxp3(+) regulatory T cells. Unlike anti-CD200R1, anti-CD200R2 both promotes  development of DCs with capacity to induce Treg and directly augments thymocyte  production of Treg.

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