Large-scale PEGylation study on 15 different proteins and characterization of 61 entities

Large-Scale Biophysical Evaluation of Protein PEGylation Effects: In Vitro Properties of 61 Protein Entities

Only limited public data is available on the biophysical effects of protein PEGylation, even though PEGylation is the most widely used method to chemically modify protein biopharmaceuticals. The first large-scale study, with site-specific mono-PEGylation of 15 different proteins and characterization of 61 entities using a common set of analytical methods was reported in a recent publication. (Read full publication…)

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