A series of PEG covered bimetallic (Au-Pd) nanostructures have been developed by Prof. R. D. Tilley group (University of New South Wales, Australia), which have shown high efficiency of photothermal hyperthermia therapy. In order to stabilize the bimetallic nanostructure for in vitro and in vivo hyperthermia studies, poly(ethylene glycol) diamine (H2N-PEG-NH2) was chosen as the surfactant to conjugated with the bimetallic nanastructes through a simple ligand exchange process. Furthermore, the long PEG backbone is effective for imparting steric stability, preventing aggregation of the nanostructures. Surface modification with PEG products also ensures good tumor uptake of nanomaterials and minimizes immunological response. These PEG products modified Au-Pd bimetallic nanostructures irradiated with 808 nm laser light caused destruction of HeLa cells in vitro, as well as complete destruction of tumor xenographs in mouse model in vivo for effective photothermal hyperthermia. [Reference: http://pubs.acs.org/doi/abs/10.1021/acsnano.5b05563]
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