Cynomolgus CD155/PVR Antibody


Catalog #: ABCESPA1417
Product Features
Immunogen: Recombinant Cynomolgus CD155 protein 
Clonality:  Rabbit PAb
Isotype: Rabbit IgG
Buffer: Produced in rabbits immunized with purified, recombinant Cynomolgus CD155 (rC CD155; Catalog#90005-C08H; NP_001036851.1; Met 1-Asn 343). Total IgG was purified by Protein A affinity chromatography .
Reactivity: Cynomolgus
Specificity: Cynomolgus PVR / CD155
Application: ELISA
Recommend dilution:  ELISA: 0.5-1 μg/mL. This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Cynomolgus CD155. The detection limit for Cynomolgus CD155 is approximately 0.0049 ng/well.
Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Background: CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

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